15 Mars – Soutenance de thèse de Doctorat de Mr Stéphane URCUN

16 h Salle des Conseils, aux Arts et Métiers de Paris

Sujet : Mechano-biology of tumor growth with the aim of clinical application, a reactive multiphase poromechanical approach

Résumé

This work focuses on the numerical modelling of glioblastoma isocitrate dehydrogenase wild-type (GBMwt) and builds upon the following hypotheses: the brain tissue is a porous medium, the coupling of hypoxia consequences and mechanical interplay between extra-cellular matrix and tumor cells is the driver of the malignant evolution of the disease. First, a review, with a large scope, was done on mechanical application in clinical management of cancer. Then, a poromechanical model was developed with the aim of a clinical application in oncology. The model was first validated on in vitro experimental data of encapsulated multi-cellular spheroids. Then, a clinical collaboration was initiated with the Neuro-imaging center of Toulouse, and the targeted clinical application was the modeling of non-operable GBMwt. To this end, the model was first adapted to the specificity of brain tissue mechanics. Characteristic features of the disease were modelled: necrotic core, modified extra-cellular matrix production, emerging malignant phenotype and invasion. Clinical imaging data were pre-processed to inform the model in a patient specific basis. A proposition of modelling was provided with an evaluation against clinical data.

Composition du jury

  • Vittorio Cristini, Professeur, Houston Methodist Hospital (Weill Cornell Medical College) - Examinateur     
  • Olga Barrera, Senio Lecturer, University of Oxford (Department of engineering science) - Rapporteur
  • Alfio Grillo, Assosiate Professor, Politecnico di Torino (Collegio di Ingegneria Civile) - Rapporteur
  • Hector Gomez, Professeur, Purdue University (School of Mechanical Engineering) - Examinateur
  • Wafa Skalli, Professeur émérite, Arts et Métiers (Institut de Biomécanique Humaine Georges Charpak) - Directrice de thèse
  • Stéphane P.A. Bordas, Professeur, Université du Luxembourg (Faculty of Science, Technology and Medicine) - Co-Directeur de thèse
  • Giuseppe Sciumè, MCF-HDR, Université de Bordeaux (Institut de mécanique et d'ingénierie) - Co-encadrant de thèse
  • Pierre-Yves Rohan, MCF, Arts et Métiers (Institut de Biomécanique Humaine Georges Charpak) - Co-encadrant de thèse

Lieu

Localisation de l’événement